Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans.

• Main Authors: Thomas C Darton (Author), Christoph J Blohmke (Author), Eleni Giannoulatou (Author), Claire S Waddington (Author), Claire Jones (Author), Pamela Sturges (Author), Craig Webster (Author), Hal Drakesmith (Author), Andrew J Pollard (Author), Andrew E Armitage (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Iron is a key pathogenic determinant of many infectious diseases. Hepcidin, the hormone responsible for governing systemic iron homeostasis, is widely hypothesized to represent a key component of nutritional immunity through regulating the accessibility of iron to invading microorganisms...