Luteolin enhances erlotinib's cell proliferation inhibitory and apoptotic effects in glioblastoma cell lines

• Main Authors: Erika Powe (Author), Daniel Parschauer (Author), Jessica Istifan (Author), Stacy Lin (Author), Huanyun Duan (Author), Rebecca Gryka (Author), Denise Jean-Louis (Author), Amit K. Tiwari (Author), Samson Amos (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The epidermal growth factor (EGFR) receptor is frequently overexpressed in glioblastoma multiforme IV (GBM). Increased expression of EGFR leads to increased proliferation, decreased apoptosis, and increased resistance to chemotherapeutic agents. A small molecule called erlotinib inhibits EGFR recept...