Andersen-Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1

• Váldodahkkit: Reem Handklo-Jamal (Dahkki), Eshcar Meisel (Dahkki), Daniel Yakubovich (Dahkki), Leonid Vysochek (Dahkki), Roy Beinart (Dahkki), Michael Glikson (Dahkki), Julie R. McMullen (Dahkki), Nathan Dascal (Dahkki), Eyal Nof (Dahkki), Shimrit Oz (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Andersen-Tawil syndrome (ATS) type-1 is associated with loss-of-function mutations in KCNJ2 gene. KCNJ2 encodes the tetrameric inward-rectifier potassium channel Kir2.1, important to the resting phase of the cardiac action potential. Kir-channels' activity requires interaction with the agonist...