Andersen-Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1

Andersen-Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1

Andersen-Tawil syndrome (ATS) type-1 is associated with loss-of-function mutations in KCNJ2 gene. KCNJ2 encodes the tetrameric inward-rectifier potassium channel Kir2.1, important to the resting phase of the cardiac action potential. Kir-channels' activity requires interaction with the agonist...

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Main Authors: Reem Handklo-Jamal (Author), Eshcar Meisel (Author), Daniel Yakubovich (Author), Leonid Vysochek (Author), Roy Beinart (Author), Michael Glikson (Author), Julie R. McMullen (Author), Nathan Dascal (Author), Eyal Nof (Author), Shimrit Oz (Author)
Format: Book
Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
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