Regulation of the Cav1.2 cardiac channel by redox via modulation of CaM interaction with the channel

• Main Authors: Yu Sun (Author), Jianjun Xu (Author), Etsuko Minobe (Author), Shoken Shimoara (Author), Liying Hao (Author), Masaki Kameyama (Author)
• Format: Book
• Published: Elsevier, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although it has been well documented that redox can modulate Cav1.2 channel activity, the underlying mechanisms are not fully understood. In our study, we examined the effects of redox on Cav1.2 channel activity and on CaM interaction with the Cav1.2 α1 subunit. Dithiothreitol (DTT, 1 mM) in the cel...