The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism

• Main Authors: Orestes Foresto-Neto (Author), Ana Ruth Paolinetti Alves da Silva (Author), Marcella Cipelli (Author), Fernanda Paula Roncon Santana-Novelli (Author), Niels Olsen Saraiva Camara (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kidneys are sensitive to disturbances in oxygen homeostasis. Hypoxia and activation of the hypoxia-inducible factor (HIF) pathway alter the expression of genes involved in the metabolism of renal and immune cells, interfering with their functioning. Whether the transcriptional activity of HIF protec...