Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors

• मुख्य लेखकों: Zhenzhen Liu (लेखक), Taoqian Zhao (लेखक), Zhonghua Li (लेखक), Kai Sun (लेखक), Yundong Fu (लेखक), Ting Cheng (लेखक), Jimin Guo (लेखक), Bin Yu (लेखक), Xiaojing Shi (लेखक), Hongmin Liu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Ubiquitin specific peptidase 28 (USP28) is closely associated to the occurrence and development of various malignancies, and thus has been validated as a promising therapeutic target for cancer therapy. To date, only few USP28 inhibitors with moderate inhibitory activity have been reported, highly p...