Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors

• Main Authors: Zhenzhen Liu (Author), Taoqian Zhao (Author), Zhonghua Li (Author), Kai Sun (Author), Yundong Fu (Author), Ting Cheng (Author), Jimin Guo (Author), Bin Yu (Author), Xiaojing Shi (Author), Hongmin Liu (Author)
• Format: Book
• Published: Elsevier, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ubiquitin specific peptidase 28 (USP28) is closely associated to the occurrence and development of various malignancies, and thus has been validated as a promising therapeutic target for cancer therapy. To date, only few USP28 inhibitors with moderate inhibitory activity have been reported, highly p...