Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells

• Main Authors: Qiongqiong Jia (Author), Boqun Liu (Author), Xuan Dang (Author), Yanjie Guo (Author), Xiaoyu Han (Author), Tinglin Song (Author), Jung-Chien Cheng (Author), Lanlan Fang (Author)
• Format: Book
• Published: BMC, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Growth differentiation factor-11 (GDF-11) belongs to the transforming growth factor-β (TGF-β) superfamily. To date, the expression of GDF-11 in the ovary and its role in regulating ovarian function are completely unknown. Ovarian granulosa cell-mediated steroidogenesis plays a pi...