Lin28 Inhibits the Differentiation from Mouse Embryonic Stem Cells to Glial Lineage Cells through Upregulation of Yap1

• Main Authors: Juan Luo (Author), Hailin Zou (Author), Liang Deng (Author), Xiang Sun (Author), Ping Yuan (Author), Peng Li (Author)
• Formato: Livro
• Publicado em: Hindawi Limited, 2021-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The RNA-binding protein Lin28 regulates neurogliogenesis in mammals, independently of the let-7 microRNA. However, the detailed regulatory mechanism remains obscured. Here, we established Lin28a or Lin28b overexpression mouse embryonic stem cells (ESCs) and found that these cells expressed similar l...