Induction of Multiple Drug Transporters by Efavirenz

• Main Authors: Johanna Weiss (Author), Melanie Herzog (Author), Sonja König (Author), Caroline Henrike Storch (Author), Nahal Ketabi-Kiyanvash (Author), Walter Emil Haefeli (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Efavirenz, an important component of human immunodeficiency virus 1 (HIV-1) therapy, causes substantial drug interactions as an inducer of cytochromes and the transporter ABCB1. So far its effect on the expression of other transporters is unknown. We therefore investigated the effect of long-term ex...