Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations

• Main Authors: Mingrong Lv (Author), Chunyu Liu (Author), Chunjie Ma (Author), Hui Yu (Author), Zhongmei Shao (Author), Yang Gao (Author), Yiyuan Liu (Author), Huan Wu (Author), Dongdong Tang (Author), Qing Tan (Author), Junqiang Zhang (Author), Kuokuo Li (Author), Chuan Xu (Author), Hao Geng (Author), Jingjing Zhang (Author), Hang Li (Author), Xiaohong Mao (Author), Lei Ge (Author), Feifei Fu (Author), Kaixin Zhong (Author), Yuping Xu (Author), Fangbiao Tao (Author), Ping Zhou (Author), Zhaolian Wei (Author), Xiaojin He (Author), Feng Zhang (Author), Yunxia Cao (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Potassium channels are important for the structure and function of the spermatozoa. As a potassium transporter, the mSlo3 is essential for male fertility as Slo3 knockout male mice were infertile with the series of functional defects in sperm cells. However, no pathogenic variant...