In-cell bioluminescence resonance energy transfer (BRET)-based assay uncovers ceritinib and CA-074 as SARS-CoV-2 papain-like protease inhibitors
Papain-like protease (PLpro) is an attractive anti-coronavirus target. The development of PLpro inhibitors, however, is hampered by the limitations of the existing PLpro assay and the scarcity of validated active compounds. We developed a novel in-cell PLpro assay based on BRET and used it to evalua...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
Taylor & Francis Group,
2024-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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