Methanol extract of semen Ziziphi Spinosae attenuates ethanol withdrawal anxiety by improving neuropeptide signaling in the central amygdala

• Main Authors: Li Bo Li (Author), Young Woo Kim (Author), Yu Hua Wang (Author), Li Bai (Author), Xiao Dong Zhu (Author), Zheng Lin Zhao (Author), Chul Won Lee (Author), Yu Jiao (Author), Tong Wu (Author), Zhen Zhen Cai (Author), Sang Chan Kim (Author), Won G. An (Author), Chae Ha Yang (Author), Guang Cheng Cui (Author), Rong Jie Zhao (Author)
• Format: Book
• Published: BMC, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ethanol withdrawal (EtOHW) anxiety is a crucial risk factor for alcoholic relapse. The neuropeptide nociceptin/orphanin FQ (N/OFQ) acts upon its receptor (NOP) to antagonize corticotropin-releasing factor (CRF) and elicit anxiolytic actions. Semen Ziziphi Spinosae (SZS), a protot...