Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence

• Main Authors: Jinyi Liu (Author), Xiangjin Zheng (Author), Wan Li (Author), Liwen Ren (Author), Sha Li (Author), Yihui Yang (Author), Hong Yang (Author), Binbin Ge (Author), Guanhua Du (Author), Jianyou Shi (Author), Jinhua Wang (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lung cancer is by far the leading cause of cancer death worldwide, and 85% of patients are diagnosed with non-small cell lung cancer (NSCLC), which is still very difficult to treat. Skp2 functions as an oncogene that participates in processes of many cancers. Here, we report a novel Skp2 inhibitor A...