Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

• 主要な著者: Kenneth C McCullough (著者), Isabelle Bassi (著者), Panagiota Milona (著者), Rolf Suter (著者), Lisa Thomann-Harwood (著者), Pavlos Englezou (著者), Thomas Démoulins (著者), Nicolas Ruggli (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2014-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Self-amplifying replicon RNA (RepRNA) possesses high potential for increasing antigen load within dendritic cells (DCs). The major aim of the present work was to define how RepRNA delivered by biodegradable, chitosan-based nanoparticulate delivery vehicles (nanogel-alginate (NGA)) interacts with DCs...