CRISPA: A Non-viral, Transient Cas9 Delivery System Based on Reengineered Anthrax Toxin

• मुख्य लेखकों: Maximilian Hirschenberger (लेखक), Nicole Stadler (लेखक), Maximilian Fellermann (लेखक), Konstantin M. J. Sparrer (लेखक), Frank Kirchhoff (लेखक), Holger Barth (लेखक), Panagiotis Papatheodorou (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Translating the CRISPR/Cas9 genome editing technology into clinics is still hampered by rather unspecific, unsafe and/or inconvenient approaches for the delivery of its main components - the Cas9 endonuclease and a guide RNA - into cells. Here, we describe the development of a novel transient and no...