Efficient Sleeping Beauty DNA Transposition From DNA Minicircles

• Main Authors: Nynne Sharma (Author), Yujia Cai (Author), Rasmus O Bak (Author), Martin R Jakobsen (Author), Lisbeth Dahl Schrøder (Author), Jacob Giehm Mikkelsen (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA transposon-based vectors have emerged as new potential delivery tools in therapeutic gene transfer. Such vectors are now showing promise in hematopoietic stem cells and primary human T cells, and clinical trials with transposon-engineered cells are on the way. However, the use of plasmid DNA as...