Predicting Paclitaxel Disposition in Humans With Whole‐Body Physiologically‐Based Pharmacokinetic Modeling

• المؤلفون الرئيسيون: Qiang Fu (مؤلف), Xinxin Sun (مؤلف), Maryam B. Lustburg (مؤلف), Alex Sparreboom (مؤلف), Shuiying Hu (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2019-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Paclitaxel is a commonly used drug in the treatment of multiple solid tumors, including cancers of the breast, lung, and ovaries. Despite the established exposure-pharmacodynamic relationships for paclitaxel, treatment is associated with wide interindividual pharmacokinetic variability that leads to...