Predicting Paclitaxel Disposition in Humans With Whole‐Body Physiologically‐Based Pharmacokinetic Modeling

• Главные авторы: Qiang Fu (Автор), Xinxin Sun (Автор), Maryam B. Lustburg (Автор), Alex Sparreboom (Автор), Shuiying Hu (Автор)
• Формат: ‌
• Опубликовано: Wiley, 2019-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Paclitaxel is a commonly used drug in the treatment of multiple solid tumors, including cancers of the breast, lung, and ovaries. Despite the established exposure-pharmacodynamic relationships for paclitaxel, treatment is associated with wide interindividual pharmacokinetic variability that leads to...