The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages

• Main Authors: Yanping Wu (Author), Xiang Luo (Author), Qingqing Zhou (Author), Haibiao Gong (Author), Huaying Gao (Author), Tongzheng Liu (Author), Jiaxu Chen (Author), Lei Liang (Author), Hiroshi Kurihara (Author), Yi-Fang Li (Author), Rong-Rong He (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies; however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis contributed to the psychological stress-evoked tumor s...