Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction

• Main Authors: Elizabeth J. Wright (Author), Nigel W. Hodson (Author), Michael J. Sherratt (Author), Moustapha Kassem (Author), Andrew L. Lewis (Author), Christine Wallrapp (Author), Nadim Malik (Author), Cathy M. Holt (Author)
• 格式: 圖書
• 出版: Hindawi Limited, 2016-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Background. Mesenchymal stem cells (MSCs) and glucagon-like peptide-1 (GLP-1) are being tested as treatment strategies for myocardial infarction (MI); however, their mechanisms in the heart are not fully understood. Methods. We examined the effects of MSCs, either native, or engineered to secrete a...