EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development.

• Main Authors: Zhe Cheng (Author), Fan Liu (Author), Xiu Li (Author), Mengya Dai (Author), Jianjian Wu (Author), Xinrui Guo (Author), Huimin Tian (Author), Zhijie Heng (Author), Ying Lu (Author), Xiaoli Chai (Author), Yanhai Wang (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Larvae of the tapeworm E. multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. A population of stem cell-like cells, the germinative cells, is considered to drive the larval growth and development within the host. The molecular mechani...