The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target.

• Main Authors: Bo Wu (Author), Jacopo Novelli (Author), Jeremy Foster (Author), Romualdas Vaisvila (Author), Leslie Conway (Author), Jessica Ingram (Author), Mehul Ganatra (Author), Anita U Rao (Author), Iqbal Hamza (Author), Barton Slatko (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Filarial parasites (e.g., Brugia malayi, Onchocerca volvulus, and Wuchereria bancrofti) are causative agents of lymphatic filariasis and onchocerciasis, which are among the most disabling of neglected tropical diseases. There is an urgent need to develop macro-filaricidal drugs, as current anti-fila...