A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy
Epidermolytic palmoplantar keratoderma (EPPK) is a relatively common autosomal-dominant skin disorder caused by mutations in the keratin 9 gene (KRT9), with few therapeutic options for the affected so far. Here, we report a knock-in transgenic mouse model that carried a small insertion-deletion (ind...
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Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Book |
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Elsevier,
2016-01-01T00:00:00Z.
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A1234.567 |
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Copy 1 | Available |