A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy

• मुख्य लेखकों: Ya-Su Lyu (लेखक), Pei-liang Shi (लेखक), Xiao-Ling Chen (लेखक), Yue-Xiao Tang (लेखक), Yan-Fang Wang (लेखक), Rong-Rong Liu (लेखक), Xiao-Rui Luan (लेखक), Yu Fang (लेखक), Ru-Huan Mei (लेखक), Zhen-Fang Du (लेखक), Hai-Ping Ke (लेखक), Erik Matro (लेखक), Ling-En Li (लेखक), Zhao-Yu Lin (लेखक), Jing Zhao (लेखक), Xiang Gao (लेखक), Xian-Ning Zhang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2016-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Epidermolytic palmoplantar keratoderma (EPPK) is a relatively common autosomal-dominant skin disorder caused by mutations in the keratin 9 gene (KRT9), with few therapeutic options for the affected so far. Here, we report a knock-in transgenic mouse model that carried a small insertion-deletion (ind...