A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy

Epidermolytic palmoplantar keratoderma (EPPK) is a relatively common autosomal-dominant skin disorder caused by mutations in the keratin 9 gene (KRT9), with few therapeutic options for the affected so far. Here, we report a knock-in transgenic mouse model that carried a small insertion-deletion (ind...

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Main Authors: Ya-Su Lyu (Author), Pei-liang Shi (Author), Xiao-Ling Chen (Author), Yue-Xiao Tang (Author), Yan-Fang Wang (Author), Rong-Rong Liu (Author), Xiao-Rui Luan (Author), Yu Fang (Author), Ru-Huan Mei (Author), Zhen-Fang Du (Author), Hai-Ping Ke (Author), Erik Matro (Author), Ling-En Li (Author), Zhao-Yu Lin (Author), Jing Zhao (Author), Xiang Gao (Author), Xian-Ning Zhang (Author)
Format: Book
Published: Elsevier, 2016-01-01T00:00:00Z.
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