Inflammatory degranulation of the cardiac resident mast cells suppresses the pacemaking and affects activation pattern in the sinoatrial node

• Main Authors: Vlad S. Kuzmin (Author), Inna A. Malykhina (Author), Ksenia B. Pustovit (Author), Alexandra D. Ivanova (Author), Marcin Kuniewicz (Author), Jerzy Walocha (Author), Andrew Atkinson (Author), Abimbola J. Aminu (Author), Halina Dobrzynski (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Many bacterial and viral infections may cause sepsis or/and systemic or local proinflammatory responses that lead to life-threatening cardiovascular system failure. Severe bradycardia and/or bradyarrhythmias frequently accompany systemic inflammation and contribute to hemodynamic insuffi...