Anti-inflammatory effects of saxagliptin and vildagliptin against doxorubicin-induced nephrotoxicity in rats: attenuation of NLRP3 inflammasome up-regulation and tubulo-interstitial injury

• Những tác giả chính: Rasha Ezzat Mostafa (Tác giả), Azza Hassan Morsi (Tác giả), Gihan Farag Asaad (Tác giả)
• Định dạng: Sách
• Được phát hành: Wolters Kluwer Medknow Publications, 2021-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Background and purpose: The clinical use of the chemotherapeutic drug, doxorubicin (DXR), is significantly limited by its extensive multi-organ toxicity. Dipeptidyl peptidase-4 (DPP4) is over-expressed in oxidative stress, inflammation and apoptosis. DPP4 inhibitors have proven pleiotropic effects....