Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA

• Main Authors: Marek P. Dąbrowski (Author), Wanda Stankiewicz (Author), Tadeusz Płusa (Author), Andrzej Chciałowski (Author), Stanisław Szmigielski (Author)
• Format: Book
• Published: Hindawi Limited, 2001-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Human peripheral blood mononuclear cells (PBMC) left in microcultures for 24 h without mitogen do not respond to subsequent stimulation with PHA. They regain reactivity if the native culture medium is absorbed with other party lymphocytes or partially replaced with the medium from a PHA-...