4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis

• Main Authors: Daniela Secci (Author), Simone Carradori (Author), Anél Petzer (Author), Paolo Guglielmi (Author), Melissa D'Ascenzio (Author), Paola Chimenti (Author), Donatella Bagetta (Author), Stefano Alcaro (Author), Gokhan Zengin (Author), Jacobus P. Petzer (Author), Francesco Ortuso (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents were linked to N1 of the hydrazone in order t...