2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels

• Main Authors: Hagit Neumann-Raizel (Author), Asaf Shilo (Author), Shaya Lev (Author), Maxim Mogilevsky (Author), Ben Katz (Author), David Shneor (Author), Yoav D. Shaul (Author), Andreas Leffler (Author), Alberto Gabizon (Author), Rotem Karni (Author), Alik Honigman (Author), Alexander M. Binshtok (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeted delivery of therapeutic compounds to particular cell types such that they only affect the target cells is of great clinical importance since it can minimize undesired side effects. For example, typical chemotherapeutic treatments used in the treatment of neoplastic disorders are cytotoxic n...