Self-sufficient nanoparticles with dual-enzyme activity trigger radical storms and activate cascade-amplified antitumor immunologic responses

• Main Authors: Liping Bai (Author), Jin Yang (Author), Siting Yu (Author), Zhongzheng Xiang (Author), Yuanyuan Zeng (Author), Meiling Shen (Author), Xiaorong Kou (Author), Qinjie Wu (Author), Changyang Gong (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Radiotherapy (RT) can potentially induce systemic immune responses by initiating immunogenic cell death (ICD) of tumor cells. However, RT-induced antitumor immunologic responses are sporadic and insufficient against cancer metastases. Herein, we construct multifunctional self-sufficient nanoparticle...