Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model

• Main Authors: Galen W. Heyne (Author), Joshua L. Everson (Author), Lydia J. Ansen-Wilson (Author), Cal G. Melberg (Author), Dustin M. Fink (Author), Kia F. Parins (Author), Padydeh Doroodchi (Author), Caden M. Ulschmid (Author), Robert J. Lipinski (Author)
• Format: Book
• Published: The Company of Biologists, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Holoprosencephaly (HPE) is a common and severe human developmental abnormality marked by malformations of the forebrain and face. Although several genetic mutations have been linked to HPE, phenotypic outcomes range dramatically, and most cases cannot be attributed to a specific cause. Gene-environm...