Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism

• Main Authors: Gisela Geoghegan (Author), Judith Simcox (Author), Marcus M. Seldin (Author), Timothy J. Parnell (Author), Chris Stubben (Author), Steven Just (Author), Lori Begaye (Author), Aldons J. Lusis (Author), Claudio J. Villanueva (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Activation of the Wnt-signaling pathway is known to inhibit differentiation in adipocytes. However, there is a gap in our understanding of the transcriptional network regulated by components of the Wnt-signaling pathway during adipogenesis and in adipocytes during postnatal life. The key...