Pharmacological β-adrenoceptor blockade can augment torsadogenic action of IKr inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventricular block dogs

• Main Authors: Ai Goto (Author), Mihoko Hagiwara-Nagasawa (Author), Koki Chiba (Author), Ryuichi Kambayashi (Author), Yoshio Nunoi (Author), Hiroko Izumi-Nakaseko (Author), Akio Matsumoto (Author), Yasunari Kanda (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Information is still limited whether β-blockade may augment or attenuate the onset of torsade de pointes in patients with IKr inhibitor-induced labile repolarization process. We compared the proarrhythmic effects of d-sotalol with those of dl-sotalol using the chronic atrioventricular block dogs, si...