Pharmacological β-adrenoceptor blockade can augment torsadogenic action of IKr inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventricular block dogs

• Autori principali: Ai Goto (Autore), Mihoko Hagiwara-Nagasawa (Autore), Koki Chiba (Autore), Ryuichi Kambayashi (Autore), Yoshio Nunoi (Autore), Hiroko Izumi-Nakaseko (Autore), Akio Matsumoto (Autore), Yasunari Kanda (Autore), Atsushi Sugiyama (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2019-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Information is still limited whether β-blockade may augment or attenuate the onset of torsade de pointes in patients with IKr inhibitor-induced labile repolarization process. We compared the proarrhythmic effects of d-sotalol with those of dl-sotalol using the chronic atrioventricular block dogs, si...