Enhanced Supersaturation via Fusion-Assisted Amorphization during FDM 3D Printing of Crystalline Poorly Soluble Drug Loaded Filaments

• Hoofdauteurs: Guluzar Gorkem Buyukgoz (Auteur), Christopher Gordon Kossor (Auteur), Rajesh N. Davé (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2021-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Filaments loaded with griseofulvin (GF), a model poorly water-soluble drug, were prepared and used for 3D printing via fused deposition modeling (FDM). GF was selected due to its high melting temperature, enabling lower temperature hot-melt extrusion (HME) keeping GF largely crystalline in the filam...