Gold Nanoparticles Inhibit Steroid-Insensitive Asthma in Mice Preserving Histone Deacetylase 2 and NRF2 Pathways

• Main Authors: Magda F. Serra (Author), Amanda C. Cotias (Author), Andreza S. Pimentel (Author), Ana Carolina S. de Arantes (Author), Ana Lucia A. Pires (Author), Manuella Lanzetti (Author), Jandir M. Hickmann (Author), Emiliano Barreto (Author), Vinicius F. Carvalho (Author), Patrícia M. R. e Silva (Author), Renato S. B. Cordeiro (Author), Marco Aurélio Martins (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Gold nanoparticles (AuNPs) can inhibit pivotal pathological changes in experimental asthma, but their effect on steroid-insensitive asthma is unclear. The current study assessed the effectiveness of nebulized AuNPs in a murine model of glucocorticoid (GC)-resistant asthma. Methods: A/J m...