Identification of Glycine Receptor α3 as a Colchicine-Binding Protein

• Main Authors: Xikun Zhou (Author), Mingbo Wu (Author), Yongmei Xie (Author), Guo-Bo Li (Author), Tao Li (Author), Rou Xie (Author), Kailun Wang (Author), Yige Zhang (Author), Chaoyu Zou (Author), Wenling Wu (Author), Qi Wang (Author), Xiangwei Wang (Author), Ximu Zhang (Author), Jiong Li (Author), Jing Li (Author), Yu-Quan Wei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colchicine (Col) is considered a kind of highly effective alkaloid for preventing and treating acute gout attacks (flares). However, little is known about the underlying mechanism of Col in pain treatment. We have previously developed a customized virtual target identification method, termed IFPTarg...