BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells

• Main Authors: Da-Sheng Zhang (Author), Yuan-Yi Li (Author), Xiao-Jun Chen (Author), Yu-Juan Li (Author), Zhao-Ying Liu (Author), Wen-Jian Xie (Author), Zhi-Liang Sun (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous studies show that several pathways are involved in sanguinarine-induced apoptotic cell death, including AKT downregulation, inhibition of NF-kB activation, mediation of ROS production, downregulation of anti-apoptosis proteins XIAP and cIAP-1, upregulation of BAX, and downregulation of BCL2...