Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs

• Главные авторы: Laura Hellinen (Автор), Sina Bahrpeyma (Автор), Anna-Kaisa Rimpelä (Автор), Marja Hagström (Автор), Mika Reinisalo (Автор), Arto Urtti (Автор)
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• Опубликовано: MDPI AG, 2020-06-01T00:00:00Z.
• Предметы: article
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Interactions between drugs and melanin pigment may have major impacts on pharmacokinetics. Therefore, melanin binding can modify the efficacy and toxicity of medications in ophthalmic and other disease of pigmented tissues, such as melanoma. As melanin is present in many pigmented tissues in the hum...