Analysis of the presence of FLT3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients

• Main Authors: Graciele Burnatt (Author), Marley Aparecida Licínio (Author), Pâmela Cristina Gaspar (Author), Arthur Schveitzer Ferreira (Author), Manoela Lira Reis (Author), Ana Carolina Rabello de Moraes (Author), Thaís Cristine Marques Sincero (Author), Maria Cláudia Santos-Silva (Author)
• Format: Book
• Published: Universidade de São Paulo, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT When the FLT3 gene is mutated, it originates a modified receptor with structural changes, which give survival advantage and malignant hematopoietic cell proliferation. Thus, the presence of mutations in this gene is considered an unfavorable prognostic factor. A total of 85 consecutive samp...