Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

• Main Authors: Ali J. Chakera (Author), Paul S. Hurst (Author), Gill Spyer (Author), Emmanuel O. Ogunnowo-Bada (Author), William J. Marsh (Author), Christine H. Riches (Author), Chen-Yu Yueh (Author), S. Pauliina Markkula (Author), Jeffrey W. Dalley (Author), Roger D. Cox (Author), Ian A. Macdonald (Author), Stephanie A. Amiel (Author), Kenneth M. MacLeod (Author), Lora K. Heisler (Author), Andrew T. Hattersley (Author), Mark L. Evans (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Appropriate glucose levels are essential for survival; thus, the detection and correction of low blood glucose is of paramount importance. Hypoglycemia prompts an integrated response involving reduction in insulin release and secretion of key counter-regulatory hormones glucagon and epine...