Fluorescence Cross-Correlation Spectroscopy Yields True Affinity and Binding Kinetics of <i>Plasmodium</i> Lactate Transport Inhibitors

• Main Authors: Iga Jakobowska (Author), Frank Becker (Author), Stefano Minguzzi (Author), Kerrin Hansen (Author), Björn Henke (Author), Nathan Hugo Epalle (Author), Eric Beitz (Author), Stefan Hannus (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Blocking lactate export in the parasitic protozoan <i>Plasmodium falciparum</i> is a novel strategy to combat malaria. We discovered small drug-like molecules that inhibit the sole plasmodial lactate transporter, PfFNT, and kill parasites in culture. The pentafluoro-3-hydroxy-pent-2-en-1...