Belzutifan, HIF-2α Inhibitor, and Clear Cell Renal Cell Carcinoma With Somatic Von-Hippel-Lindau Loss-of-Function Mutation

• প্রধান লেখক: Kok Hoe Chan MD (লেখক), Ningjing Li MD (লেখক), Ran Lador MD (লেখক), Mark Amsbaugh MD (লেখক), Anneliese Gonzalez MD (লেখক), Putao Cen MD (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: SAGE Publishing, 2024-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The Von-Hippel-Lindau (VHL) gene, acting as a tumor suppressor, plays a crucial role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Approximately 90% of individuals with advanced ccRCC exhibit somatic mutations in the VHL gene. Belzutifan, orally administered small-molecule inhibit...