Role of the gp85/trans-sialidases in Trypanosoma cruzi tissue tropism: preferential binding of a conserved peptide motif to the vasculature in vivo.

• Main Authors: Renata R Tonelli (Author), Ricardo J Giordano (Author), Elena Magda Barbu (Author), Ana Claudia Torrecilhas (Author), Gerson S Kobayashi (Author), Robert R Langley (Author), Wadih Arap (Author), Renata Pasqualini (Author), Walter Colli (Author), Maria Júlia M Alves (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Transmitted by blood-sucking insects, the unicellular parasite Trypanosoma cruzi is the causative agent of Chagas' disease, a malady manifested in a variety of symptoms from heart disease to digestive and urinary tract dysfunctions. The reasons for such organ preference have been a...