Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody

• Main Authors: Yongjun Yin (Author), Xiaodi Ren (Author), Craig Smith (Author), Qianxu Guo (Author), Maria Malabunga (Author), Ilhem Guernah (Author), Yiwei Zhang (Author), Juqun Shen (Author), Haijun Sun (Author), Nabil Chehab (Author), Nick Loizos (Author), Dale L. Ludwig (Author), David M. Ornitz (Author)
• Format: Book
• Published: The Company of Biologists, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects. In human lung cancer, fibroblast growth factor 9 (FGF9), a high-affinity ligand for FGFR3, is overexpressed in 10% of primary resected non-small...