Differential Effects of a Novel Opioid Ligand UTA1003 on Antinociceptive Tolerance and Motor Behaviour

• Main Authors: Alok K. Paul (Author), Krystel L. Woolley (Author), Mohammed Rahmatullah (Author), Polrat Wilairatana (Author), Jason A. Smith (Author), Nuri Gueven (Author), Nikolas Dietis (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Analgesic tolerance is a major problem in the clinic for the maintenance of opioid-induced long-term pain relief. Opioids with mixed activity on multiple opioid receptors promise reduced antinociceptive tolerance in preclinical studies, but these compounds typically show poor bioavailability upon or...