Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells

• Main Authors: Lianhong Pan (Author), Fan Feng (Author), Jiaqin Wu (Author), Shibing Fan (Author), Juanjuan Han (Author), Shunxi Wang (Author), Li Yang (Author), Wanqian Liu (Author), Chunli Wang (Author), Kang Xu (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer stem cells drive tumor initiation, progression, and recurrence, which compromise the effectiveness of anti-tumor drugs. Here, we report that demethylzeylasteral (DML), a triterpene anti-tumor compound, suppressed tumorigenesis of liver cancer stem cells (LCSCs) by interfering with lactylation...