A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts

• Main Authors: Jun Kanazawa (Author), Haruna Kitazawa (Author), Hironori Masuko (Author), Yohei Yatagai (Author), Tohru Sakamoto (Author), Yoshiko Kaneko (Author), Hiroaki Iijima (Author), Takashi Naito (Author), Takefumi Saito (Author), Emiko Noguchi (Author), Satoshi Konno (Author), Masaharu Nishimura (Author), Tomomitsu Hirota (Author), Mayumi Tamari (Author), Nobuyuki Hizawa (Author)
• Format: Book
• Published: BMC, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The chitinase-like protein YKL-40 plays a major role in inhibiting the inflammasome. Deregulation of inflammasome activation is emerging as a key modulator of pathologic airway inflammation in patients with asthma. We determined whether cis-expression quantitative trait loci (eQT...