A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts

• প্রধান লেখক: Jun Kanazawa (লেখক), Haruna Kitazawa (লেখক), Hironori Masuko (লেখক), Yohei Yatagai (লেখক), Tohru Sakamoto (লেখক), Yoshiko Kaneko (লেখক), Hiroaki Iijima (লেখক), Takashi Naito (লেখক), Takefumi Saito (লেখক), Emiko Noguchi (লেখক), Satoshi Konno (লেখক), Masaharu Nishimura (লেখক), Tomomitsu Hirota (লেখক), Mayumi Tamari (লেখক), Nobuyuki Hizawa (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2019-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background The chitinase-like protein YKL-40 plays a major role in inhibiting the inflammasome. Deregulation of inflammasome activation is emerging as a key modulator of pathologic airway inflammation in patients with asthma. We determined whether cis-expression quantitative trait loci (eQT...