Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway

• Główni autorzy: Yi Yang (Autor), Na Li (Autor), Tongshuai Chen (Autor), Chunmei Zhang (Autor), Lingxin Liu (Autor), Yan Qi (Autor), Peili Bu (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Context: Sunitinib (SU) is a multi-targeted tyrosine kinase inhibitor anticancer agent whose clinical use is often limited by cardiovascular complications. Trimetazidine (TMZ) is an anti-angina agent that has been demonstrated cardioprotective effects in numerous cardiovascular conditions, but its p...