Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis

Bromodomain containing protein 4 (BRD4), as an epigenetic reader, can specifically bind to the acetyl lysine residues of histones and has emerged as an attractive therapeutic target for various diseases, including cancer, cardiac remodeling and heart failure. Herein, we described the discovery of hi...

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Main Authors: Zhangxu He (Author), Haomiao Jiao (Author), Qi An (Author), Xin Zhang (Author), Dan Zengyangzong (Author), Jiale Xu (Author), Hongmin Liu (Author), Liying Ma (Author), Wen Zhao (Author)
Format: Book
Published: Elsevier, 2022-01-01T00:00:00Z.
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