Loss of intestinal sympathetic innervation elicits an innate immune driven colitis

• Main Authors: Rose A. Willemze (Author), Olaf Welting (Author), Patricia van Hamersveld (Author), Caroline Verseijden (Author), Laurens E. Nijhuis (Author), Francisca W. Hilbers (Author), Sybren L. Meijer (Author), Balthasar A. Heesters (Author), Joost H. A. Folgering (Author), Harold Darwinkel (Author), Philippe Blancou (Author), Margriet J. Vervoordeldonk (Author), Jurgen Seppen (Author), Sigrid E. M. Heinsbroek (Author), Wouter J. de Jonge (Author)
• Format: Book
• Published: BMC, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to investigate the role of sympathetic innervation to the intestine on regulatio...