Modulation of Kynurenic Acid Production by N-acetylcysteine Prevents Cognitive Impairment in Adulthood Induced by Lead Exposure during Lactation in Mice

• Príomhchruthaitheoirí: Paulina Ovalle Rodríguez (Údar), Daniela Ramírez Ortega (Údar), Tonali Blanco Ayala (Údar), Gabriel Roldán Roldán (Údar), Gonzalo Pérez de la Cruz (Údar), Dinora Fabiola González Esquivel (Údar), Saúl Gómez-Manzo (Údar), Laura Sánchez Chapul (Údar), Aleli Salazar (Údar), Benjamín Pineda (Údar), Verónica Pérez de la Cruz (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2023-11-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Lead (Pb²⁺) exposure during early life induces cognitive impairment, which was recently associated with an increase in brain kynurenic acid (KYNA), an antagonist of NMDA and alpha-7 nicotinic receptors. It has been described that N-acetylcysteine (NAC) favors an antioxidant en...