Modulation of Kynurenic Acid Production by N-acetylcysteine Prevents Cognitive Impairment in Adulthood Induced by Lead Exposure during Lactation in Mice

• Auteurs principaux: Paulina Ovalle Rodríguez (Auteur), Daniela Ramírez Ortega (Auteur), Tonali Blanco Ayala (Auteur), Gabriel Roldán Roldán (Auteur), Gonzalo Pérez de la Cruz (Auteur), Dinora Fabiola González Esquivel (Auteur), Saúl Gómez-Manzo (Auteur), Laura Sánchez Chapul (Auteur), Aleli Salazar (Auteur), Benjamín Pineda (Auteur), Verónica Pérez de la Cruz (Auteur)
• Format: Livre
• Publié: MDPI AG, 2023-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Lead (Pb²⁺) exposure during early life induces cognitive impairment, which was recently associated with an increase in brain kynurenic acid (KYNA), an antagonist of NMDA and alpha-7 nicotinic receptors. It has been described that N-acetylcysteine (NAC) favors an antioxidant en...