Modulation of Kynurenic Acid Production by N-acetylcysteine Prevents Cognitive Impairment in Adulthood Induced by Lead Exposure during Lactation in Mice

• Main Authors: Paulina Ovalle Rodríguez (Author), Daniela Ramírez Ortega (Author), Tonali Blanco Ayala (Author), Gabriel Roldán Roldán (Author), Gonzalo Pérez de la Cruz (Author), Dinora Fabiola González Esquivel (Author), Saúl Gómez-Manzo (Author), Laura Sánchez Chapul (Author), Aleli Salazar (Author), Benjamín Pineda (Author), Verónica Pérez de la Cruz (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lead (Pb²⁺) exposure during early life induces cognitive impairment, which was recently associated with an increase in brain kynurenic acid (KYNA), an antagonist of NMDA and alpha-7 nicotinic receptors. It has been described that N-acetylcysteine (NAC) favors an antioxidant en...