Modulation of Kynurenic Acid Production by N-acetylcysteine Prevents Cognitive Impairment in Adulthood Induced by Lead Exposure during Lactation in Mice

• Asıl Yazarlar: Paulina Ovalle Rodríguez (Yazar), Daniela Ramírez Ortega (Yazar), Tonali Blanco Ayala (Yazar), Gabriel Roldán Roldán (Yazar), Gonzalo Pérez de la Cruz (Yazar), Dinora Fabiola González Esquivel (Yazar), Saúl Gómez-Manzo (Yazar), Laura Sánchez Chapul (Yazar), Aleli Salazar (Yazar), Benjamín Pineda (Yazar), Verónica Pérez de la Cruz (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2023-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Lead (Pb²⁺) exposure during early life induces cognitive impairment, which was recently associated with an increase in brain kynurenic acid (KYNA), an antagonist of NMDA and alpha-7 nicotinic receptors. It has been described that N-acetylcysteine (NAC) favors an antioxidant en...